Scientists identify a new molecular mechanism for autism

Image: A confocal microscopy image of synaptophysin expression in Shank3 mutant primary cortical neurons treated with nitric oxide inhibitor. (Dr. Tripathi of the Amal Lab at The Hebrew University). © Provided by The Times of Israel. Article by Sukanya Charuchandra. Advanced Science News – May 22, 2023.

High levels of nitric oxide, a signaling chemical in the brain, appear to contribute to the behavioral deficits observed in autism.

From a myriad of data obtained from experiments in mouse models, human stem cells, clinical blood samples, and human cell cultures, new research published in the journal Advanced Science suggest that nitric oxide changes the functioning and structure of neurons and leads to autism-like behaviors. Autism spectrum disorders (ASDs) comprise a vast group of neurodevelopmental conditions […]

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