Scientists Discover That a Single Dose of Psilocybin Changes the Human Brain

Photo: Psilocybe allenii growing on irrigated wood chips in the San Francisco Bay Area, fruiting in November – November 16, 2025. Photo credit: Martin.jambon via Wikimedia Commons. CC BY 4.0 (no modifications). Article by Levi Gadye. University of California – San Francisco. SciTechDaily – May 13, 2026. Research article: Nature Communications.

Researchers discovered that psilocybin temporarily increases brain complexity and may reshape neural connections for weeks.

Researchers at UC San Francisco and Imperial College London have found that a single dose of psilocybin, the psychedelic compound in magic mushrooms, may cause physical changes in the brain that last for as long as a month after use. […]

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