Does St. John’s wort really increase serotonin?

Photo: Common Saint John’s Wort – Hypericum perforatum – June 25, 2016. Photo credit: Björn S… via Flickr. CC BY-SA 2.0. Article by Clarissa Brincat. Popular Science – August 26, 2025.

Search online for “natural antidepressants” and St. John’s wort will most certainly pop up. The herbal supplement, sold in capsules, tablets, teas, and tinctures, has long been promoted as a remedy for depression. People who are reluctant to take synthetic antidepressant drugs like Prozac are often drawn to this “natural remedy.” […]

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