Holographic Ultrasound Breakthrough Enables Scientists to Unlock a New Frontier in Brain Stimulation Research

Image – Fig. 1: Noninvasive, precise and highly controllable delivery of ultrasound perturbations to the mouse brain. Image credit – Estrada, H., Chen, Y., Lemaire, T. et al. Holographic transcranial ultrasound neuromodulation enhances stimulation efficacy by cooperatively recruiting distributed brain circuits. Nature Biomedical Engineering. CC BY 4.0 (no modifications). Article by Ryan Whalen. The Debrief – October 6, 2025. Research article: Nature Biomedical Engineering.

Researchers have developed a method to repurpose existing ultrasound technologies to manipulate neural activity—a process known as neuromodulation—potentially marking a new approach to treating Alzheimer’s disease. While ultrasound has long been used to monitor fetal development or destroy tumors with high-intensity bursts, using it to directly influence neural activity has only been explored in laboratory settings over the past decade. […]

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