# Holographic Ultrasound Breakthrough Enables Scientists to Unlock a New Frontier in Brain Stimulation Research

- Link: https://www.widthness.com/holographic-ultrasound-breakthrough-enables-scientists-to-unlock-a-new-frontier-in-brain-stimulation-research/
- Published: 2025-10-07T09:30:00-05:00
- Author: Curated by John Wysocki

Image – Fig. 1: Noninvasive, precise and highly controllable delivery of ultrasound perturbations to the mouse brain. Image credit – Estrada, H., Chen, Y., Lemaire, T. et al. Holographic transcranial ultrasound neuromodulation enhances stimulation efficacy by cooperatively recruiting distributed brain circuits. Nature Biomedical Engineering. CC BY 4.0 (no modifications). Article by Ryan Whalen. The Debrief – October 6, 2025. Research article: Nature Biomedical Engineering. Researchers have developed a method to repurpose existing ultrasound technologies to manipulate neural activity—a process known as neuromodulation—potentially marking a new approach to treating Alzheimer’s disease. While ultrasound has long been used to monitor fetal development or destroy tumors with high-intensity bursts, using it to directly influence neural activity has only been explored in laboratory settings over the past decade. […] Click here to view original web page at www.thedebrief.org Curated by John Wysocki See Full Bio