Protein p53’s Role in Autism-like Behavior and Memory

Image credit: Neuroscience News. Article by Jenna Kurtzweil. Neuroscience News – September 28, 2023. Source: University of Illinois. Original Research: Closed access.
“Tumor suppressor p53 modulates activity-dependent synapse strengthening, autism-like behavior and hippocampus-dependent learning.”

Summary: Scientists have discovered a direct link between the protein p53 and autism-like behavior in mice. The researchers studied the effects of manipulating p53 levels in the mouse hippocampus. Reduced levels resulted in repetitive behavior, diminished sociability, and impaired learning, especially in male mice. This pivotal work uncovers the intricate role of p53 in neurodevelopmental disorders like autism. […]

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