Scientists uncover anti-aging “glue” that naturally repairs damaged DNA

Image: 3D modeling of DNA, created with the free software Blender – February 6, 2021. Image credit: Tim Tim (VD fr) via Wikimedia. CC BY-SA 4.0 (no modifications). Article by Mihai Andrei. ZME Science – June 20, 2025. Research article: Aging Cell.

A new study published in Aging Cell reveals that a well-known enzyme, long known for its involvement with cancer, actually steps into the nucleus to help repair DNA. This enzyme is Protein Disulphide Isomerase (PDI), known for ensuring proteins fold correctly inside the cell. But researchers from Macquarie University and La Trobe University have uncovered a surprising second role. PDI also helps patch double-stranded DNA breaks, acting like a glue to bind the DNA together. […]

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