Taming the immune response to gluten to treat celiac disease

Image caption: The structure of the kumamolisin-As enzyme from the acidophilic bacterium Alicyclobacillus sendaiensis provided a starting point for engineering a gluten-degrading enzyme that is active in the acidic conditions of the stomach. Image credit: Research Collaboratory for Structural Bioinformatics Protein Data Bank. Article by Sarah Anderson, PhD. Drug Discovery News – May 23, 2023.

Researchers develop gluten-degrading enzymes to administer as drugs or incorporate into food and explore therapies that block downstream disease checkpoints.

An oral biologist, a computational protein engineer, and a food scientist walk into a bar. They grab a few pints of beer, snatch some pretzels, and head back to the lab to run experiments with their glutenous loot. While listing them sounds like the start of a bad joke, […]