Scientists Discover Plant Compound That Forces Aggressive Breast Cancer Cells Into Self-Destruction

Image: DHL-11 competes with FANCI to bind IMPDH2, destabilizing it, reducing GMP synthesis, causing DNA damage and replication stress, and inducing TNBC cell apoptosis. Image credit: Yu Zhu, et al. via ScienceDirect. CC BY-NC-ND 4.0 (no modifications). Article by SciTechDaily.com. SciTechDaily – March 2, 2026. Research article: DHL-11, a novel prieurianin-type limonoid isolated from Munronia henryi, targeting IMPDH2 to inhibit triple-negative breast cancer.

A newly discovered plant-derived molecule disrupts a critical cancer enzyme in an unconventional way.

Scientists looking for new ways to tackle hard-to-treat breast cancers turned to an unexpected source: Munronia henryi, a plant known for producing limonoids, a family of complex natural compounds that plants often use for chemical defense. […]

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