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Protein Region Is Central to Parkinson’s Pathology

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Protein Region Is Central to Parkinson's Pathology
Photo caption: The powerful 950 MHz nuclear magnetic resonance machine that allowed researchers to make their discovery. Credit: University of Leeds. Original story from the University of Leeds in England.

A master control region of a protein linked to Parkinson’s disease has been identified for the first time.

The finding, made by scientists from the University of Leeds’ Astbury Centre for Structural Molecular Biology, provides a new target for the development of therapies to try and slow down or even prevent the disease. Parkinson’s affects more than 10 million people across the world, causing neurodegeneration and difficulties with movement, which increase over time. There is currently no cure for the disease. The study focused on a protein called alpha-synuclein, which is linked to the onset and progression of Parkinson’s disease. Alpha-synuclein is found in healthy cells in the nervous system, but problems arise when it clumps together, or aggregates, into plaques known as amyloid that can disrupt normal function. […]

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