Rheumatoid arthritis treated with implanted cells that release drug

Image: Guilak Lab / Washington University School of Medicine. Article by Jim Dryden, Washington University in St. Louis. Technology.org – September 1, 2021.

With a goal of developing rheumatoid arthritis therapies with minimal side effects, researchers at Washington University School of Medicine in St. Louis have genetically engineered cells that, when implanted in mice, will deliver a biologic drug in response to inflammation.

The engineered cells reduced inflammation and prevented a type of damage to bone, known as bone erosion, in a mouse model of rheumatoid arthritis. The research team’s ultimate aim is to develop therapies for people coping with rheumatoid arthritis, a debilitating condition that affects about 1.3 million adults in the United States. […]

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